Identification and characterization of codon usage pattern and influencing factors in HFRS-causing hantaviruses

Hemorrhagic fever with renal syndrome (HFRS) is an acute viral zoonosis carried and transmitted by infected rodents through urine, droppings, or saliva. The etiology of HFRS complex due to the involvement factors host immune genetic which hinder development potential therapeutic solutions for HFRS. Hantaan virus (HTNV), Dobrava-Belgrade (DOBV), Seoul (SEOV), Puumala (PUUV) are predominantly found in hantaviral species that cause patients. Despite ongoing prevention control efforts, remains a serious economic burden worldwide. Furthermore, recent studies reported hantavirus nucleocapsid protein multi-functional plays major role replication cycle hantavirus. However, precise mechanism nucleoproteins pathogenesis not completely understood. In framework current study, various silico approaches were employed identify influencing codon usage pattern nucleoproteins. Based on relative synonymous (RSCU) values, comparative analysis was performed between HFRS-causing their hosts, suggesting HTNV, DOBV, SEOV, PUUV, inclined evolve patterns comparable those hosts. results indicated most overrepresented codons had AU-endings, revealed mutational pressure force shaping patterns. influence natural selection geographical cannot be ignored bias. Further also demonstrated causing hantaviruses adapted host-specific sustain successful transmission chains within To our knowledge, no study date Thus, proposed computational scheme can help understanding underlying lend helping hand designing effective anti-HFRS treatments future. This although comprehensive, relies methods thus necessitates experimental validation more solid outcomes. Beyond identified behavior, there could other yet undiscovered influences. These should targets further research improve strategies.